Hydrocodone is a generic medication sold under the brand name Hysingla and others. It is an opioid analgesic to treat severe long-term pain when other treatment options are not sufficient.
People also buy hydrocodone online for cough suppression in adults. It is an oral medication usually available in combination with acetaminophen and ibuprofen. As a single-ingredient product, hydrocodone comes only as a long-acting formulation medicine.
Hydrocodone got patented in 1923, and its long-acting formulation got approval for medical use in the year 2013 in the United States. The wholesale cost of a long-acting hydrocodone is about $10 to $30 per dose as of 2019.
It is one of the most commonly prescribed medications in the United States, which consumes about 80-90% of the worldwide supply of hydrocodone.
Manufacturers derive hydrocodone from opium poppy after converting it to codeine. It is almost similar to morphine in terms of efficacy and effectiveness; hydrocodone 10 mg is equivalent to morphine oral 10 mg.
What are the uses of hydrocodone?
You can buy hydrocodone online to treat moderate to chronic pain. Its liquid formulation is useful in treating cough. A study comparing hydrocodone and oxycodone’s potency demonstrates that oxycodone is about 50% more potent than hydrocodone.
However, a study of emergency department patients with fractures shows that an equal amount of both the medications provided the same pain-relieving effects, which indicates that there is very little practical difference between these two when used for the same purpose.
Analgesic actions of hydrocodone typically start within 20-30 minutes and last about 4-6 hours. Therefore, it recommended dosing interval is usually 4-6 hours.
Are there any side effects of hydrocodone?
Hydrocodone also causes side effects along with its needed effects. Most frequently occurring adverse effects of hydrocodone include:
- Mood swings
- Dry throat
- Difficult urination
- Skin rash
- Contraction of pupils
Hydrocodone misuse may cause progressive bilateral hearing loss that does not respond to steroid therapy. This adverse reaction is rare and occurs due to the ototoxicity of hydrocodone.
The medication is in the C pregnancy category of the U.S. Food and Drug Administration. A baby born of a mother regularly taking hydrocodone will be physically dependent on the medication. The infant might exhibit respiratory depression if hydrocodone doses were high.
Hydrocodone may be habit-forming, even at recommended dosages. It can cause physical or psychological dependence and has a high potential for abuse and addiction.
How hydrocodone affects our body?
Hydrocodone is a selective full mu-opioid receptor agonist. It is the primary target of endogenous opioids. Hydrocodone has a less affinity for the delta-opioid receptor (DOR) and k opioid receptor (KOR).
Studies show that hydrocodone is more potent than codeine at binding to receptors, but only 59% as potent as morphine in terms of analgesic properties. However, tests conducted on animals demonstrate that the analgesic potency of hydrocodone is actually higher than morphine.
What drugs interact with hydrocodone?
Hydrocodone interacts with several drugs to produce additive central nervous system depression. If you are on the dosage of this medication, avoid taking alcohol, any other opioid, alcoholic beverages, antipsychotics, anticholinergics, antihistamines, anti-anxiety drugs, or other central nervous system depressants with it.
Hydrocodone also interacts with serotonergic medications to produce serotonin syndrome.
You should not consume any drug that interacts with hydrocodone concurrently with it. Consult your prescribing doctor and ask for a complete list of all the interacting prescription and non-prescription medications and other drugs.
What are the available dosage formulations of hydrocodone?
You can order hydrocodone online both in single-ingredient and combination formulations. It comes in a variety of oral administration formulations:
- The original form of single-ingredient hydrocodone is Dicodid, as 5 mg and 10 mg immediate-release tablets. This medication is not available in the United States.
- A combination of hydrocodone and homatropine, Hycodan, are small tablets for treating cough.
- Extended-release hydrocodone is available as a time-release syrup containing chlorphenamine, known as Tussionex. It is also a cough medication popular in North America.
- A combination of hydrocodone and acetaminophen as immediate-release tablets, namely Lortab, Vicodin, Norco, Lorcet, Zydone, and Maxidone.
- A combination of hydrocodone and ibuprofen as immediate-release tablets, namely Ibudone, Vicoprofen, and Reprexain.
- A combination of hydrocodone and aspirin as immediate-release tablets, namely Lortab ASA, Alor 5/500, Panasal 5/500, and Azdone.
- Controlled-release hydrocodone as Zohydro ER or Hysingla ER.